He is best known as co-founder, lead vocalist, guitarist, bassist and co-songwriter of the alternative rock band Failure. He has also played in Replicants, a cover band side project that also included members of Tool. After the breakup of Failure in 1997, he also recorded music under the moniker ON, and later assembled and fronted the band Year of the Rabbit. He has performed as a solo artist, as well as collaborating in a self-described "digital band" called Digital Noise Academy with Justin Meldal-Johnsen, Sharky Laguana (Creeper Lagoon), Jordon Zadorozny, and Charlotte Martin (whom Andrews married in 2005), among others. In 2014, Andrews reunited with Failure members Greg Edwards and Kellii Scott. They embarked on a North American tour, which included two dates performing alongside A Perfect Circle and Puscifer for the celebration of Maynard James Keenan's 50th birthday.